Pazopanib treatment for kidney cancer represents a significant advancement in targeted therapy, having received U.S. Food and Drug Administration (FDA) approval in 2009 for advanced renal cell carcinoma (RCC). This drug provided a new and effective option for patients, particularly those with advanced or metastatic RCC. As a tyrosine kinase inhibitor (TKI), pazopanib targets multiple pathways, including vascular endothelial growth factor (VEGF) receptors, platelet-derived growth factor (PDGF) receptors, and c-Kit, which are involved in cancer cell growth and spread. Its mechanism of action includes inhibiting these receptors, thereby blocking the growth of new blood vessels to tumors (angiogenesis) and limiting cancer cell proliferation. Pazopanib is indicated for patients with advanced RCC, especially effective in treating clear cell RCC, the most common RCC subtype. It is administered orally in tablet form, making it convenient for outpatient treatment. The dosage of pazopanib may be
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